Rejex polymer coating review4/9/2023 Balloon catheters are also successfully used to manage tear ducts, paranasal sinuses, or salivary glands disorders. In recent years, stents and balloon catheters have reached a significant position in the treatment of this condition. One such disease is an obstructive arterial disease affecting millions of people around the world. Heart diseases are particularly important in this aspect. In the treatment of many diseases, it is crucial to control the dosing of a drug for a long time and thus maintain its optimal concentration in the tissue. We illustrate that what materials were used, how they were designed and fabricated into coatings, and what goals the composite coatings realized.Ĭontrolled drug delivery is a matter of interest to numerous scientists from various domains, as well as an essential issue for society as a whole. We introduce metal and metal oxide-based, carbon-based, ceramic-based, and silica-based composite coatings. In this review, we summarize the inorganic-polymer composite biomedical coatings. The inorganic-polymer composite coatings would be much more qualified to enhance biocompatibility and bioactivity of the medical devices, showing great potentials in biomedical applications. ![]() By combining polymers and inorganic materials, researchers can fabricate coatings with the advantages of both components. Polymers and inorganic materials are the most used components in the medical coatings, while they both show limitations. Biomedical devices can thus satisfy the clinical requirements to a better extent with the help of coatings. By fabricating coatings, the biocompatibility of the devices would be significantly improved, and their biofunctions would be multiplied. Medical coatings are now playing key roles in the practical use of biomedical devices. Wound healing studies of the coated PDMS samples in mice models showed a reduction in bacteria concentration as compared to uncoated PDMS, indicating in vivo efficacy potential of the developed catheter coating platform. The full scale ‘AMP-EC-PCL’-coated catheter showed improved mechanical integrity compared to commercial silicone catheters with preservation of the catheter balloon integrity upon expansion. Fifteen centimeter catheter segments of single layer ‘AMP-EC-PCL’-coated catheters showed sustainable AMP release kinetics up to 7 days, where good antibacterial and anti-biofilm activity against E. The coating also showed excellent anti-biofilm capability against green fluorescent protein (GFP)-tagged UTI E. The ‘AMP-EC-PCL’ coating showed good anti-bacteria performance against uropathogenic Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa for up to 6 days. Sustained peptide release was achieved with the development of an Ethyl Cellulose (EC): 1-Palmitoyl-2-oleoylphosphatidylcholine (POPC)-based diffusion layer over an AMP-laden Polycaprolactone (PCL)-based layer to control AMP diffusion into the environment over a clinically relevant duration. This study aims to deploy a novel and potentially cost-effective technique to coat an anhydrous polymeric coating impregnated with AMPs for silicone-based catheters, to overcome limitations in conventional hydrogel-based coatings. ![]() The incorporation of AMPs in catheter coatings has gained interest due to the effective bacteria killing effects of AMPs, with few reports on bacterial resistance development against peptides. Although silver- or antibiotics-coated catheters have been deployed to minimise CAUTI, the inconsistency and lack of durability in antibacterial properties of these coatings have limited their clinical use. Catheter associated urinary tract infection (CAUTI) is a common nosocomial infection among hospitalized patients and is a major reservoir of antimicrobial resistant pathogens. ![]() This study reports the development of a polymer-based catheter coating to facilitate controlled release of antimicrobial peptides (AMP) to target both planktonic bacteria and biofilm in the urinary catheter environment.
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